Microbial Toxins and Diarrhoeal Disease

Symposium on Microbial Toxins.

In arranging the symposium on microbial precise information supporting this belief has toxins, an attempt was made to stress those been obtained in studies of dysentery bacilli, aspects in this general field which have not been the Shiga bacillus by British workers, and the discussed frequently. It is for this reason that Flexner bacillus by Goebel in this country. Less emphasis was placed on t...

Studies of food hygiene and diarrhoeal disease.

Contamination of weaning foods and water with enteropathogenic micro-organisms has been recognised in the past, but its link with the development of diarrhoea by young children in developing countries is lacking. This may explain the unavailability of effective interventions to reduce the risk of diarrhoeal diseases from this contamination. The frequency of contamination of weaning foods with e...

Traveller’s Diarrhoea and Intestinal Protozoal Diarrhoeal Disease

Microbes and microbial toxins: paradigms for microbial-mucosal interactions II. The integrated response of the intestine to Clostridium difficile toxins.

Clostridium difficile, the major etiologic factor of antibiotic-associated diarrhea and colitis, mediates its effects by releasing two large protein exotoxins, toxins A and B. A major toxin effect is related to the disassembly of actin microfilaments, leading to impairment of tight junctions in human colonocytes. The mechanism of actin disaggregation involves monoglucosylation of the signaling ...

©international Centre for Diarrhoeal Disease Research, Bangladesh

Each year, an estimated six million perinatal deaths occur worldwide, and 98% of these deaths occur in lowand middle-income countries. These estimates are based on surveys in both urban and rural areas, and they may underrepresent the problem in rural areas. This study was conducted to quantify perinatal mortality, to identify the associated risk factors, and to determine the most common causes...